منابع مشابه
Non-interference by Unfolding
The concept of non-interference has been introduced to characterise the absence of undesired information flows in a computing system. Although it is often explained referring to an informal notion of causality the activity involving the part of the system with higher level of confidentiality should not cause any observable effect at lower levels it is almost invariably formalised in terms of in...
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Conditionally disordered proteins can alternate between highly ordered and less ordered configurations under physiological conditions. Whereas protein function is often associated with the ordered conformation, for some of these conditionally unstructured proteins, the opposite applies: Their activation is associated with their unfolding. An example is the small periplasmic chaperone HdeA, whic...
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Protein unfolding is a key step in the import of some proteins into mitochondria and chloroplasts and in the degradation of regulatory proteins by ATP-dependent proteases. In contrast to protein folding, the reverse process has remained largely uninvestigated until now. This review discusses recent discoveries on the mechanism of protein unfolding during translocation into mitochondria. The mit...
متن کاملIntransitive Non-Interference by Unfolding
Non-interference characterizes the absence of undesired information flows in a computing system, by requiring that activities involving actions with higher level of confidentiality does not cause any observable effect at the lower level. Recently, a causal characterisation of non-interference on Petri nets has been given in terms of the unfolding semantics, a classical true concurrent semantics...
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Notch signaling regulates many aspects of metazoan development and tissue renewal. Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human disorders, from developmental syndromes to adult-onset diseases and cancer. Notch signaling is remarkably robust in most tissues even though each Notch molecule is irreversibly activated by proteolysis and signals only once ...
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ژورنال
عنوان ژورنال: Science
سال: 2013
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.339.6119.490-b